F-star Therapeutics, Inc.

Crescendo Biologics is a biopharmaceutical company developing conditionally-activated T cell enhancing therapeutics, with a particular focus on CD137 (4-1BB).

The innovative, first and best in class programmes are designed to activate only tumour-specific T cells in the tumour micro-environment and not outside it. This approach is expected to reduce the toxicities experienced with traditional immunotherapies and also to lead to the proliferation of tumour-specific T cells with a broad, long-lasting anti-tumour response.

Our lead programme, CB307, is a CD137 (4-1BB) x PSMA bispecific for PSMA-positive tumours. CB307’s unique format delivers highly potent tumour-specific killing, while avoiding systemic toxicity and can be applied to a broad range of PSMA-positive cancer indications.

Crescendo’s pipeline is underpinned by its novel, patent-protected Humabody® platform, which generates fully human VH domains (Humabodies). Humabodies are matured in vivo in the absence of any light-chains and are robust and stable molecules. Humabody VH domains can be easily assembled into multi-specific formats which can access novel biology and deliver superior tumour accumulation and penetration compared to conventional monoclonal antibody-based approaches.

The Humabody platform has received third party validation through its strategic, multi-target collaboration in immuno-oncology, ADCs and CAR-Ts with Takeda, worth up to $790M, and from licensing its first programme for an inflammatory target to Zai Lab in 2018. In 2020 Crescendo entered into a Clinical Development Partnership with Cancer Research UK to progress CB213, a PD-1 x LAG-3 bispecific, into the clinic.

Crescendo is progressing novel Humabody®-based product opportunities, through in-house development and strategic collaborations as well as seeking strategic partners to develop novel Humabody therapeutics leveraging our in-house expertise and our pipeline of Humabody molecules.

Explicyte is a family brand of specialty preclinical services launched by ImmuSmol, a bordeaux-based company. The first brand, Explicyte Immune-Oncology offers preclinical contract research services in immuno-oncology.

Explicyte Immuno-Oncology currently offers to test innovative cancer immunotherapies in vivo, using syngeneic mouse tumor models treated with immune checkpoint inhibitors (eg. anti-CTLA-4 and anti-PD1/PD-L1 antibodies). In addition, Explicyte is setting up an in vitro platform for the identification and optimization of novel immunomodulators. Equipped with high-content analysis technologies, the platform focuses on live phenotypic screening in co-cultures of immune and cancer cells, as well as molecular cell-based assays for the assessment of immune checkpoint inhibitors.

We deliver vital health information, at the time it matters.

High-tech company for innovative laboratory diagnostics and research services with strong focus on Rare Diseases and Newborn Screening. From Inborn Errors of Metabolism to Oncology we make personalized diagnostics more accessible.
We provide everything from routine tests to clinical studies and from biochemical to genetic testing.
We are dedicated to the development of novel laboratory tests that make actionable health information fast accessible.

Clinical Mass Spectrometry, Next-Generation Sequencing and development of novel assays and biomarkers for routine services and clinical research.
International Diagnostic Services for Biotech & Pharma companies.
ARCHIMEDlife Research Institute for academic research, - omics and biomarker discovery.

Cmed is an innovative, full service, technology-led CRO, established in 2000 by a team of experts passionate about helping customers deliver highly successful clinical trials. We bring together an experienced team and our own innovative technology to drive real progress throughout the clinical trial process – for every step, every solution, every study. Our vision is to conduct clinical trials better than anyone else to help patients and ultimately save lives.

We have earned a strong reputation for successfully delivering complex, demanding and innovative clinical trials in various therapeutic areas, with specialist therapeutic expertise in oncology, cell & gene therapy, rare disease and in data & analytics.

Further information about Cmed’s full suite of services is available at www.cmedresearch.com.

To see the latest career opportunities at Cmed, visit www.cmedresearch.com/openpositions

Ablynx, a Sanofi company, is engaged in the development of Nanobodies®, proprietary therapeutic proteins based on single-domain antibody fragments, which combine the advantages of conventional antibody drugs with some of the features of small-molecule drugs. Nanobodies have potential uses in the treatment of a range of serious and life-threatening human diseases. Ablynx advances a portfolio of Nanobody-based therapeutic programs in several major disease areas, including inflammation, haematology, immuno-oncology and oncology.

The acquisition of Ablynx (June 2018) continues Sanofi’s commitment to breakthrough innovation, focused on technologies addressing multiple disease targets with single multi-specific molecules. Sanofi is committed to accelerating Ablynx’s Nanobody development programmes.