Crescendo Biologics is a biopharmaceutical company developing conditionally-activated T cell enhancing therapeutics, with a particular focus on CD137 (4-1BB).
The innovative, first and best in class programmes are designed to activate only tumour-specific T cells in the tumour micro-environment and not outside it. This approach is expected to reduce the toxicities experienced with traditional immunotherapies and also to lead to the proliferation of tumour-specific T cells with a broad, long-lasting anti-tumour response.
Our lead programme, CB307, is a CD137 (4-1BB) x PSMA bispecific for PSMA-positive tumours. CB307’s unique format delivers highly potent tumour-specific killing, while avoiding systemic toxicity and can be applied to a broad range of PSMA-positive cancer indications.
Crescendo’s pipeline is underpinned by its novel, patent-protected Humabody® platform, which generates fully human VH domains (Humabodies). Humabodies are matured in vivo in the absence of any light-chains and are robust and stable molecules. Humabody VH domains can be easily assembled into multi-specific formats which can access novel biology and deliver superior tumour accumulation and penetration compared to conventional monoclonal antibody-based approaches.
The Humabody platform has received third party validation through its strategic, multi-target collaboration in immuno-oncology, ADCs and CAR-Ts with Takeda, worth up to $790M, and from licensing its first programme for an inflammatory target to Zai Lab in 2018. In 2020 Crescendo entered into a Clinical Development Partnership with Cancer Research UK to progress CB213, a PD-1 x LAG-3 bispecific, into the clinic.
Crescendo is progressing novel Humabody®-based product opportunities, through in-house development and strategic collaborations as well as seeking strategic partners to develop novel Humabody therapeutics leveraging our in-house expertise and our pipeline of Humabody molecules.
HalioDx is an immuno-oncology diagnostic company providing oncologists and drug development organizations with first-in-class Immune-based diagnostic products and services to guide cancer care and contribute to precision medicine in the era of immuno-oncology and combination therapies.
Leveraging the pioneering work of Dr Jérôme Galon, HalioDx provides a unique range of immune scoring solutions including its flagship Immunoscore® assay for the assessment of the immune contexture of a tumor, as a key determinant of patients’ outcomes and response to cancer treatments.
HalioDx has developed a unique Biopharma partnering ecosystem for the identification of clinically relevant biomarker signatures, the demonstration of their clinical utility in trials and the development and commercialization of resulting diagnostic or companion diagnostic tests. Our programs draw on our expertise and focus on immuno-oncology, a complete suite of genomic and proteomic biomarker profiling services, a world-class data analysis and biostatistics platform, and CLIA-certified laboratories with compliant facilities in Europe and in the US to develop, manufacture, register and market in vitro diagnostic (IVD) products. HalioDx has rapidly become the preferred partner of Biopharma developing therapeutic antibodies, vaccines, chemotherapies, oncolytic peptides, and CAR-T cell therapies.
Immunoscore® is an in vitro diagnostic test measuring the host immune response at the tumor site. It provides a robust, precise, quantitative, and consensus assessment of lymphocytic infiltration and has been shown to predict patient outcome and response to therapies in several indications.
Immunoscore® was included in the 2020 European Society of Medical Oncology (ESMO) Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up for Localized Colon Cancer.
Immunoscore® is commercially available in more than 20 countries.
ScreenCell was set-up with the belief that just enumerating Circulating Tumor Cells (CTCs) without easily characterizing them was not enough to allow the early detection of a disease and to potentially follow-up the cancer progression. So it designed and produced a simple but revolutionary technology allowing the fast and effective isolation of CTCs for a better cellular and molecular characterization, which is essential in cancer monitoring. This technology also contributes to the development of a new non-invasive approach to prenatal diagnosis.
Screencell is dedicated to create technologies allowing CTC to become potential end points in future oncology therapeutic arsenals, by filtering out healthy live tumor cells, thus enabling:
• Molecular biology
• Cell culture
• Enumeration and cytomorphology evaluation
For that matter, ScreenCell has designed a full range of devices (marked CE) compatible with existing In vitro Diagnostics (IVD) assays and platforms, with no need for any interface development. Our technology is now used in research studies, clinical trials, clinics and hospitals.
We truly believe that our technology can make a difference in cancer diagnostics by enabling clinicians to predict the possible metastases and to monitor the cancer therapy in real time.
We deliver vital health information, at the time it matters.
High-tech company for innovative laboratory diagnostics and research services with strong focus on Rare Diseases and Newborn Screening. From Inborn Errors of Metabolism to Oncology we make personalized diagnostics more accessible.
We provide everything from routine tests to clinical studies and from biochemical to genetic testing.
We are dedicated to the development of novel laboratory tests that make actionable health information fast accessible.
Clinical Mass Spectrometry, Next-Generation Sequencing and development of novel assays and biomarkers for routine services and clinical research.
International Diagnostic Services for Biotech & Pharma companies.
ARCHIMEDlife Research Institute for academic research, - omics and biomarker discovery.
F-star is a leading clinical-stage biopharmaceutical company delivering tetravalent bispecific antibodies for a paradigm-shift in cancer therapy. By developing medicines that seek to block tumor immune evasion, the Company’s goal is to offer patients with cancer greater and more durable benefits than current immuno-oncology treatments. Through its proprietary tetravalent, bispecific antibody (mAb²™) format, F-star is generating best-in-class drug candidates with broad therapeutic index and monoclonal antibody-like manufacturability. Building on the combined expertise of its world-class management team and scientific leadership, F-star is poised to deliver the next breakthrough immunotherapies for patients with cancer.