Diagnostic BioSystems

Founded in 2004, Pharmaron is a cutting-edge, fully integrated pharmaceutical R&D service platform supporting the life science industry. The company has invested in its people and facilities and established its comprehensive service offerings throughout the pharmaceutical R&D lifecycle. With operations in China, the US and the UK staffed by more than 11,000 employees, Pharmaron has an excellent track record in delivering end-to-end R&D solutions to its partners globally and enabling them to accelerate their novel drug discovery and development process.

Pharmaron is a contract research organization (CRO).

Services:
* Synthetic, medicinal and analytical chemistry services
* Biology services
* DMPK services
* Pharmacology services
* Drug safety assessment services
* Radiochemistry and isotopically labelled metabolism services
* Chemical & pharmaceutical development services
* Clinical development services

www.pharmaron.com

CRO - Contract Research Organization
Library Synthesis
CADD
Bioorganic Chemistry
Discovery Process Chemistry
Radiolabelled Chemical Synthesis
ChemInformatics
in vitro Biology
in vitro Screening
Structural Biology
in vivo Pharmacology
Animal Disease Models
ex vivo Pharmacology
Biomarkers
in vitro ADME
in vivo PK
PKPD
QA
Regulatory Affairs
Discovery Biologics
Process Chemistry
API Manufacturing
Material Science
Formulation Development
Drug Product Manufacturing
Toxicology
Safety Pharmacology
Genetic Toxicology
DART
Pathology
Immunotoxicity
Bioanalytical
14C / Carbon-14 Radiosynthesis
3H / Tritium Radiosynthesis
QWBA
mARG
Clinical AME
Mass Balance
Metabolite Profiling
Microdosing Phase 0
Absolute Bioavailability
DDI
First-in-Human (FIH)
Thorough QT(TQT)
Ethnobridging

Since its founding in 1992, bioWORLD has established, maintained, and succeeded in its core mission to manufacture and supply high-quality molecular tools, biological reagents, and laboratory supplies to analytical laboratories, academia institutions, and research corporations globally. bioWORLD specializes in numerous product lines for the Life Sciences and Biotechnology industries. With product focuses including bioAffinity reagents for protein purification and proteomics research, recombinant proteins and synthetic peptides, plant, microbiological, animal, and yeast media, and many other fields. In addition, bioWORLD offers services including custom peptide synthesis and antibody production.

The company's headquarters are in Dublin, Ohio, with sales offices located across the globe. Through both in-house manufacturing and supply chain acquisitions, bioWORLD supplies products to biomedical and life sciences industries. In addition, we provide custom laboratory services and formulations for R&D in the biotechnology industry. bioWORLD is a growing company, with both domestic channel partners (i.e. Fisher Scientific, Spectrum Chemical, Thomas Scientific, etc.) as well as established international distribution partners in 45 countries.

CustomArray, Inc. is a company dedicated to providing products and services to the "Omics" marketplace.

CustomArray can provide instruments such as the B3™ Synthesizer that uses semiconductor arrays to rapidly synthesize DNA arrays “on chip”. Arrays can be synthesized automatically on the instrument using either the 4x2k™, 12k™, or 90k™ array chips. In situ synthesis on up to 32 arrays (for 4x2k format) or 8 arrays (for other formats) can be performed in under 24 hours. We can also provide pre-made arrays ready for your experiment, and arrays can be read either using standard fluorescence chip readers (one-color or two-color readouts) or can be read using electrochemical detection on our ElectraSense reader. CustomArray also offers extensive services using our platforms to measure gene expression, to measure microRNA expression, to identify aptamer sequences (DNA sequences that bind with high affinity to customer-provided proteins), to identify potent siRNA sequences against select targets in vitro and validate the function of these targets both in vitro and in vivo, to provide large pools of oligos for specific applications such as sequencing, as well as other services.

More information on products and services is in the "products" section of the website. We look forward to continuing to supply essential products to previous customers and welcome new customers to explore the advantages of our technologies and services.

Drug Discovery Alliances is a provider of chemistry and formulation services bringing together scientific expertise and support during all stages of the R&D continuum for emerging biotechs, existing multinationals and the United States government. We provide a global service where our partners – located in N. America, China, Japan, Czech Republic, England, Germany and Italy – cover four key services:

Consulting
• CMC Project Management
• GMP Auditing
• Licensing
• Sourcing & Procurement

Drug Discovery
• Medicinal Chemistry

R&D/Pre-Clinical
• Analytical Method Development
• Catalysis Screening
• Crystallization
• Metabolites, Impurities ID & Synthesis
• Process Research
• Reference Standards
• Solid Form Capabilities

Manufacturing (Phase I-III)
• Advanced Intermediate Manufacturing
• API & Commercial Manufacturing
• cGMP Manufacturing
• Final Drug Product Manufacturing
• Formulation Development
• Quality and Regulatory Support
• Raw Material Manufacturing

Chemistry Technology Platforms
Aseptic Fill & Finish
• Chlorination
• Chromatography
• Cryogenic
• Distillation
• Fermentation
• Heck Reactions
• HPAPI / High Potency
• High Pressure
• High Temperature
• High Throughput / High Resolution X-ray Diffraction
• Hydrogenation
• Lyophilization
• Nitration
• Pastillation
• Phosgenation
• Polymorph Screening
• Powder Filling
• X-ray Crystallography

Project Examples
• 4 year program for development of Regulatory Starting Material supporting NDA filing for a neurology product
• Urgent API consulting for Clinical Phase III with supplier change and identified savings of $10M
• CMC project consulting on pre-IND candidates ($760M) for a CNS product licensed by Astellas
• Generic new formulation consulting supporting Clinical Phase III for 505(b)(2) for hypertension product
• Commercial API manufacture for ophthalmology product sourcing key suppliers leading to successful FDA approval
• Phase III API for antibody conjugate for oncology identifying key supplier

Princeton Separations, Inc. (PSI) is a privately-owned, manufacturing-based biotechnology company specializing in molecular separations. PSI manufactures various successful products including:

Whether you need Centri·SepTM, Centri·Sep 8TM, and Centri·Sep 96TM for dye terminator removal from DNA sequencing reactions; Centri·SpinTM products for cleanup of molecular labeling reactions from nucleic acids, proteins or carbohydrates; PCR·96TM for probe and nucleotide cleanup of PCR reactions; BAC and Big BAC preparation in gene mapping, molecular cytometry and cell imaging; Modified Sequencing Grade Endopeptidases for protein sequencing and 5 BMT activator for chemical DNA\RNA synthesis; Fluoro·SpinTM labeling and purification kits for generation and purification of fluorescent probes for proteomics and drug discovery; or Pro·Spin product line for antibody purification, we have the answer for you when it comes to molecular separations!

PSI is a registered manufacturer with the FDA and the DEA. It maintains GMP (Good Manufacturing Practice) production in a growing facility in Freehold, New Jersey, where it performs sterile manufacturing for pharmaceutical/diagnostic companies.