Dharmacon

Founded in 2004, Pharmaron is a cutting-edge, fully integrated pharmaceutical R&D service platform supporting the life science industry. The company has invested in its people and facilities and established its comprehensive service offerings throughout the pharmaceutical R&D lifecycle. With operations in China, the US and the UK staffed by more than 11,000 employees, Pharmaron has an excellent track record in delivering end-to-end R&D solutions to its partners globally and enabling them to accelerate their novel drug discovery and development process.

Pharmaron is a contract research organization (CRO).

Services:
* Synthetic, medicinal and analytical chemistry services
* Biology services
* DMPK services
* Pharmacology services
* Drug safety assessment services
* Radiochemistry and isotopically labelled metabolism services
* Chemical & pharmaceutical development services
* Clinical development services

www.pharmaron.com

CRO - Contract Research Organization
Library Synthesis
CADD
Bioorganic Chemistry
Discovery Process Chemistry
Radiolabelled Chemical Synthesis
ChemInformatics
in vitro Biology
in vitro Screening
Structural Biology
in vivo Pharmacology
Animal Disease Models
ex vivo Pharmacology
Biomarkers
in vitro ADME
in vivo PK
PKPD
QA
Regulatory Affairs
Discovery Biologics
Process Chemistry
API Manufacturing
Material Science
Formulation Development
Drug Product Manufacturing
Toxicology
Safety Pharmacology
Genetic Toxicology
DART
Pathology
Immunotoxicity
Bioanalytical
14C / Carbon-14 Radiosynthesis
3H / Tritium Radiosynthesis
QWBA
mARG
Clinical AME
Mass Balance
Metabolite Profiling
Microdosing Phase 0
Absolute Bioavailability
DDI
First-in-Human (FIH)
Thorough QT(TQT)
Ethnobridging

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Applied Biological Materials (abm) provides quality research reagents and custom services at incredible prices. We have an extensive product range to make abm your one-stop supplier for all your research needs: PCR, RT-PCR, qPCR, antibodies, siRNA, miRNA, CRISPR, stable cell lines, immortalized cell lines, growth factors, and various viral expression systems (adenovirus, lentivirus, AAV). If you can’t find what you need, please let us know; our R&D team will tailor to your needs. We also provide custom services for the more challenging or time-consuming parts of your research projects. Custom recombinant adenovirus, custom lentivirus, custom cloning, gene synthesis, protein production and sequencing services are a few examples of abm’s assortment of services available to you. Conducting research shouldn’t cost you a fortune! abm is here to help!

Please contact us for more information on any of our products and available services.

Bio-synthesis is a biology contract manufacturer of high quality nucleic acids, peptides and other molecular biology products for the research, diagnostic and therapeutic industries. Bio-Synthesis operates an ISO 9001 certified facility and is compliant with 21 CFR 210/211 and 21 CFR 820. Our solutions help advance drug discovery and bio-medical research. Founded in 1984, Bio-Synthesis is a privately held firm based in Lewisville, Texas.

Custom Peptide Specialists
Bio-Synthesis has been a provider of Peptide Synthesis services to the life science research community since 1984. We offer a complete range of premium quality peptide products ranging from bulk API polypeptides to high throughput library peptides and peptide array preparation. We also provide a large number of peptide modifications as well as peptide synthesis for diagnostic and therapeutic applications. Bio-Synthesis specializes in both, liquid phase and solid phase fmoc peptide synthesis chemistry. We have a long standing record in preparing biologically active polypeptides including long, complex and hydrophobic peptides synthesized to your specifications.

Custom Oligonucleotide Specialists
As a pioneer in oligonucleotide synthesis, Bio-Synthesis has been pursuing the development of new oligonucleotide-based techniques that can produce compounds with superior binding affinity and chemical/biological stability. As such, Bio-Synthesis has introduced a third generation of nucleic acid analogs, Bridged Nucleic Acid (BNA). These are RNA analogues which can be synthesized and spiked with DNA or RNA in order to modify the formation of nucleic acid helices.

Founded in 2000, CanAm Bioresearch is located in Winnipeg, Canada. CanAm Bioresearch is an established pharmaceutical contract research organization focused on pre-clinical drug discovery.

CanAm Advantages:

• Integrated CRO with flexible access to chemistry, biology and analytical
• Company leadership has experience discovering NCEs now on the market
• Highly competent and experienced research team - proven ability to deliver clinical candidates
• Outstanding skills to tackle difficult chemistry and solve complex problems through an integrated multi-disciplinary approach
• Customer focused: we operate as your own research team on your terms
• Central time zone convenient for all of North America and Europe

CanAm's clientele includes startup, small and large pharmaceutical companies, and academic institutions. Research contracts can range from simple chemical synthesis or single compound testing in our ADME and biological assays, to FTE-based full scale integrated discovery projects. We are experienced in protecting client confidentiality and intellectual property.

Medicinal Chemistry and Custom Chemical Synthesis Solutions
• Chemical synthesis of analogs
• Chemical libraries based on our collections of capping groups
• Rapid delivery, typically weekly
• Experience in hit to lead generation and optimization
• Difficult chemistry welcome!

Analytical Chemistry Solutions

• Pharmacokinetics experiments
• Tissue distribution
• Metabolite identification
• Stability studies
• Determination of chemical purity
• Solubility studies

Biological Solutions
Assays include:
• Biochemical
• Electrophysiological
• Metabolic stability
• Cellular penetration

FTE contracts:
• Very competitive rates compared to US and Western Europe
• Project leadership and medicinal chemistry guidance available

Fee for service contracts:

• Custom synthesis of any organic molecule
• Up to 1 kg scale synthesis

Gene Universal, located in Delaware USA, is a pioneer in the field of gene synthesis and synthetic biology. As a leading company in genomics research and applied biological technology, and with our strong technical force, unparalleled customized service and fast delivery time, we are aiming to provide more cost-effective service and product to accelerate the global research in drug discovery, biology optimization, food and agriculture, etc.

Gene Universal is specialized in the area of genetic engineering, biosystem engineering and synthetic biology. By providing our industrialized and highly intensive gene synthesis platform, we could deliver both normal and complex genes in short promised time. We have also developed sophisticated software programs to design and optimize complex gene libraries and genetic systems, with these bioinformatics tools and our high-efficiency production management systems, we are able to satisfy scientific researchers with high-efficient, low-cost, and large-scale synthetic genes and genome DNA.

Meanwhile, based on our five cutting-edge expression systems: Bacterial Expression, Mammalian Expression(293 & CHO), Yeast Expression, Insect Expression and Bacillus subtilis Expression system, we have become the one-stop vendor for your gene synthesis, protein expression, and antibody production services.

Our goal is to become the global leader in DNA synthesis and synthetic area, and to achieve the prosperous prospects of making research in life science more efficient and lower cost.