Cruinn Diagnostics

Alpha Laboratories is a family-run laboratory and diagnostic supplies business based in Eastleigh, Hampshire, UK and celebrated its 40th anniversary in 2015.

Since 1975 we have helped scientists to improve the health of the nation by sourcing and supplying specialist products from leading worldwide manufacturers.

In addition the company has developed its own brand lines of essential laboratory consumables such as the high quality Pastette® transfer pipettes, eco friendly Fastrak® pipette tips and SpeciSafe® UN3373 compliant sample packaging.

Our wide range of liquid handling pipettes, sample tubes, microtubes, microplates, PCR and general lab consumables, plus molecular biology equipment, ensure top performance in the laboratory.

Alpha Laboratories supports clinical laboratories with an extensive array of diagnostic assays, reagents and equipment. These cover blood grouping, gastroenterology, clinical chemistry, haematology, haemostasis and immunology testing, plus consumables for sample collection and transport .

We are highly experienced in faecal calprotectin testing to distinguish between IBD and IBS. We also provide Faecal Occult Blood testing materials to Bowel Cancer Screening Programmes nationwide and are involved in the transition to the use of more specific and sensitive Faecal Immunochemical Tests (FIT). Alpha Laboratories is also promoting the use of specialist assays such as new Rapid Pathogen ID technology that could vastly improve the speed of targeted treatment for sepsis.

We are a customer focused company dedicated to providing exceptional service, support and value for money for medical and laboratory professionals.

Celentyx is a human immune system focused R&D and service company specialising in immuno-oncology, inflammation and autoimmunity in vitro assays using healthy donor and patient tissues and cells.

Celentyx’s unique ImmuKnowlogy™ platform allows rapid analysis of drug action on human immune cells - from healthy donors or patients with defined clinical disease. Drawing on the World-leading expertise of Celentyx personnel, which along with our strategic relationships with the MRC Centre for Immune Regulation and the Centre for Translational Inflammation Research (at the Queen Elizabeth 'Super-hospital', Birmingham), enables the human immune system to be investigated at the highest levels of resolution.

Celentyx's ImmuKnowlogy™ services enable partners to quantify efficacy, elucidate the mechanism of action of an immunomodulatory drug, facilitate lead candidate prioritisation or identify potentially negative impact of a drug on the human immune system prior to first administration to man.

Celentyx's Novel Clinical Indication Profiling™, which applies the powerful Immuno-Profiling™ platform to reprofile (repurpose) drug candidates for diseases of the human immune system (e.g. inflammation, autoimmune disease, allergy, graft rejection, lymphoma, leukaemia), has created an increasing portfolio of valuable drug indications.

Within Basel neighbourhood and at the very heart of Europe (the triple border of France, Germany and Switzerland), Firalis is a pioneering biotechnology company, active in discovery, development and qualification of biomarkers (BM).

1) BIOMARKER PRODUCTS
Firalis develops BM-based diagnostic, prognostic and theranostic tools:
● RUO Kits (Research-Use-Only), based on validated innovative biomarkers
● IVD Tools (In Vitro Diagnostic), based on a combination of clinically qualified biomarkers

2) BIOMARKER R&D
● Development of proprietary BMs
- Cardiovascular, Inflammatory, Autoimmune and Neurology
● Drug Safety & Drug Efficacy
● Patient Stratification
● Personalized Medicine

3) BIOMARKER-RELATED CRO SERVICES
BM Discovery for laboratories, biotechs and pharmaceutical industry:
- Proteomics: Soluble biomarker measurements with several immunoassays technologies (ELISA, multiplex and high sensitivity platforms such as Luminex® BioPlex 200™, Meso Scale Discovery®, Singulex Erenna®, Protein Simple Ella™, Olink and Siemens Dimension® EXL™ 200)
- Genomics/Transcriptomics: Targeted sequencing of miRNA and mRNA (HTG EdgeSeq), lncRNA screening via Firalis proprietary platform, Next-Generation Sequencing (NGS) services (RNA-Seq, whole genome and exome sequencing, etc.) and qPCR/microfluidic qPCR (Gene Expression, SNP, CNV, etc.)
- Flow Cytometry: Immunophenotyping of preclinical and clinical samples, monitoring of pharmacodynamics on target cells in response to treatment and biomarker discovery
- Assay development and validation on various platforms, development of critical reagents (antibodies and proteins)
- Biobanking and sample repository services supported by LIMS
- Data analysis using multi-parametric statistics and development of predictive models
- Support of regulatory activities related to biomarker qualification with Health Authorities (FDA/EMA)
- Quality environment (ISO 9001, ISO 13485 (GMP), ISO 17025 (GLP/GCLP))

For more information please visit our website.

NEUROFIT, founded in 1996, is a pre-clinical CRO (Contract Research Organization) based in France and offering a comprehensive list of disease models and screening assays in the fields of psychiatry, neurology, multiple sclerosis, diabetes and pain. Neurofit works for major pharmaceutical and Biotech companies in Europe and the USA.
Neurofit’s core expertise in CNS and PNS includes animal behavior techniques, nerve conduction velocity measure, nerve fiber morphometry, primary neuronal cell cultures. Neurofit has long-standing experiences in psychiatric, neurodegenerative and autoimmune / inflammatory disorders. Our disease models are clinically relevant and predictive.
Neurofit routinely performs, as part of a study, collection of blood, serum plasma, cerebrospinal fluid as well as dissection of brain microstructures from compound-treated animals to provide customers with useful samples for their pharmacokinetic, biochemistry and immunochemistry analyses.

Pathway Diagnostics Ltd is a leading supplier of specialist clinical and research diagnostics in the UK. The Company is based in Dorking, Surrey and was established in 1998 to provide quality in-vitro diagnostic products and instrumentation to clinical, research and industrial laboratories mainly in the UK and Ireland.

The Company is highly focused on the needs of its customers and in providing the highest quality products and service. It has developed a number of partnerships with Diagnostics manufacturers in order to supply its customers with complete and innovative diagnostic solutions.

Pathway Diagnostics also manufacturers its own range of haemostasis tests and allergy, autoimmune, tryptase and calprotectin controls that are marketed internationally, together with those of Unicorn Diagnostics Ltd, through local distributors or direct from the UK. The Company also operates its independent PathQAS Quality Assurance schemes (PathQAS) for Coagulation, Allergy, Autoimmune serology, Calprotectin and Prekallikrein Activator assays, as a service to its customers.

Pathway Diagnostics Ltd and Personal Diagnostics Ltd, a company specialising in professional point of care and home diagnostic tests, are part of the Eurobio Scientific Group.