Creative Diagnostics

Affinity Biologicals, Inc. is a primary manufacturer of products used worldwide in thrombosis and hemostasis research and diagnostics. Our products include an extensive line of antibodies, conjugates, antibody pairs for immunoassay of human and animal analytes, the VisuLize line of complete ELISA kits, and a full line of human plasma products including VisuDep Immune-Depleted Factor-Deficient Plasmas, VisuCal Calibrator Plasma and VisuCon Control Plasmas. Services include protein purification, antibody production, assay development, custom manufacturing including custom lyophilization and proficiency testing materials.

For more information please visit www.affinitybiologicals.com.

Since its founding in 1992, bioWORLD has established, maintained, and succeeded in its core mission to manufacture and supply high-quality molecular tools, biological reagents, and laboratory supplies to analytical laboratories, academia institutions, and research corporations globally. bioWORLD specializes in numerous product lines for the Life Sciences and Biotechnology industries. With product focuses including bioAffinity reagents for protein purification and proteomics research, recombinant proteins and synthetic peptides, plant, microbiological, animal, and yeast media, and many other fields. In addition, bioWORLD offers services including custom peptide synthesis and antibody production.

The company's headquarters are in Dublin, Ohio, with sales offices located across the globe. Through both in-house manufacturing and supply chain acquisitions, bioWORLD supplies products to biomedical and life sciences industries. In addition, we provide custom laboratory services and formulations for R&D in the biotechnology industry. bioWORLD is a growing company, with both domestic channel partners (i.e. Fisher Scientific, Spectrum Chemical, Thomas Scientific, etc.) as well as established international distribution partners in 45 countries.

Subsidiary of Johnson & Johnson, Centocor is a biotechnology company that was founded in Philadelphia in 1979 with an initial goal of developing new diagnostic assays using monoclonal antibody technology.
In 1982 Centocor developed their first product approved by the U.S. Food and Drug Administration (FDA) — a diagnostic test used to detect the rabies virus, and in that same year transitioned into a publicly traded company. Subsequently, the company moved to a larger facility in Malvern, Pennsylvania (a northwest suburb of Philadelphia). In 1984, Centocor opened an overseas plant in Leiden, the Netherlands.
Eighteen years after its foundation, (in 1997), Centocor achieved its first year of operating profitability. In 1998, Centocor divested itself of its diagnostic division and launched its top-selling monoclonal antibody Remicade (infliximab) for its first FDA approved indication in Crohn's Disease.
In 1999, Centocor became a wholly owned subsidiary of Johnson & Johnson, the worldwide manufacturer and marketer of healthcare products. Subsequently, Remicade's market has expanded with approvals for rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, ulcerative colitis, and pediatric Crohn's disease. Remicade was approved for plaque psoriasis in September 2006.

Centocor also markets ReoPro (abciximab), a biologic agent indicated as an adjunct to coronary angioplasty (PTCA).

Since being acquired by Johnson and Johnson, Centocor has increased its annual sales from approximately $500 million to more than $2 billion. During the same period, research and development investment increased from $75 million to more than $300 million.

In 2004 Centocor purchased a new manufacturing plant in St. Louis, Missouri, and is currently opening a new manufacturing facility in County Cork, Ireland. The Dutch plant has been expanded substantially with a $250 million investment in additional production facilities, which were opened in 2006.

THE COMPANY
Golden West Biologicals, Inc.® (GWB) is a privately held company headquartered in Temecula, California. The company was formed in 1989 to directly address the needs of diagnostic medical device manufacturers by providing a reliable and cost effective source of high quality raw materials. In addition to meeting product requirements, GWB is committed to providing excellent service. Excellence in service includes, but is not limited to, on time delivery, minimal lead-time, consistent product performance and working with clients to provide solutions or develop new products that meet their unique requirements.
THE PRODUCTS
GWB offers a vast line of biological products that are critical components for the development and manufacture of immunoassays. Products include processed human sera matrices, highly purified protein fractions, disease state plasmas, antigens and antibodies. GWB has also developed the Mass Spect Gold® and Seratrol™ product lines to address customer need for ultra-low human sera for ultrasensitive testing and matrix-effect free base material for calibrators and controls. Our products are shaped by our customers with new products being developed and tailored to each customer's needs; one customer at a time. GWB provides The Products of Reference.
THE SERVICE
Service plays a major role in our commitment to provide the total partnership required by the medical
device industry. This includes on-time delivery, package integrity, proper shipping conditions as well as
complete tracking control. GWB places total customer satisfaction as the ultimate goal on its business
pursuits. Golden West Biologicals’ Blood Establishment Registration Number is 2029037. Golden West
Biologicals’ State of California FDA Device Manufacturing License Number is 47709 and 45092.

Haematologic Technologies (HT) is a large molecule CRO unlike any other. Combining world-class protein chemistry expertise, integrated large molecule analytical services, and customized products to support biopharma R&D, we accelerate large molecule drug development for clients around the globe.

HT’s services are offered from discovery through commercial GMP release of large molecule therapeutics. Not your typical large molecule CRO, HT has a specific depth of expertise in large molecule analytics, manufacturing process support, and navigation of the complex regulatory pathways from IND to BLA. Our services de-risk and speed your new drug development process.

Our scientific experts are well known in the fields of protein chemistry, advanced High Resolution Mass Spec (HRMS), Immunology, hemostasis, and novel assays to support complex large molecule therapeutic development and manufacture. Our FDA-inspected facilities operate to the highest standards of GMP compliance.

Building on our 30+ years of expertise in plasma proteins, hemostasis and blood coagulation, HT is also a leading global supplier of coagulation research reagents (plasma proteins and antibodies), custom formulated IVD/POC device reagents, as well as customized blood collection tubes to support clinical trials.

Visit us at www.haemtech.com.