Crawford Scientific Ltd

Excellence in Analytical Chemistry Since 1974

With 40 years experience, Butterworth Laboratories remains a fully independent UK contract analytical service providing Quality Control Testing, Method Development & Validation and Stability Study Storage & Testing to the pharmaceutical and related industries.

We work in partnership with our clients who not only recognise our expertise in analytical chemistry and standards of service but also value our integrity and impartiality.

Our regular inspections by the MHRA, UKAS and FDA ensure that the service you receive is at the very highest level for testing, validation and analysis.

Domainex is a fully integrated drug discovery service company based near Cambridge, UK serving pharmaceutical, biotechnology, academic and patient foundations globally. Our expertise and commitment to providing high quality services has resulted in a strong success record in drug discovery, delivering an average one candidate drug every year for the past six years.

Domainex’s highly experienced molecular, protein, structural and assay biologists plus medicinal, computational and analytical chemists can be leveraged through our CRO services. Domainex’s focus is on providing highly efficient and well considered scientific solutions to enable successful drug discovery programmes against a wide range of drug targets.

Domainex offers a range of services including:
• Medicinal chemistry (including SBDD)
• FragmentBuilder (Domainex’s proprietary fragment screening platform)
• Computational Chemistry (including LeadBuilder Domainex’s proprietary virtual screening platform)
• Assay Development and Screening (biochemical, biophysical and cell assays)
• iPSC and immune cell biology
• Protein Production
• CDH (Domainex’s proprietary technology which enables the rapid identification of stable, soluble protein domains)
• Analytical chemistry
• X-ray crystallography services

Whether your project is at an early stage of drug discovery or has already identified chemical matter, our processes have been shown to result in a 30% time-saving compared to industry standards and use less resource, allowing prudent management of your own budget.

MEDINA is an independent and non profit entity with innovative research collaborations and contracts with academic and industrial partners worldwide. We are engaged in the discovery of novel drug candidates and new biomarkers with Pharma and Biotech companies and research groups, as well as of new biotechnological products for use in crop protection for the Agrofood industry, Consumer products (Cosmetic and Nutrition) and new enzymes for industrial processes.

MEDINA owns one of the largest Collections of Microbial Strains and the most chemically diverse Natural Products Libraries with a longstanding, successful track record in delivering novel drug candidates for development as pharmaceuticals.

Our team has unique expertise in natural products microbiology, chemistry, high throughput screening, as well as a strong analytical chemistry platform for molecular structure elucidation and bioanalysis.

We are currently active in drug and biomarker discovery programs in infectious diseases (including tuberculosis and parasitic diseases), cancer, CNS, and rare diseases.

Leveraging our unique strengths in high precision-high throughput analytics and bioanalytics we are collaborating with clinical investigators in translational research programs for biomarker discovery and metabolomic profiling of patient samples.

MEDINA is a Research Organization established in the Health Sciences Technology Park, Granada (Spain) as a private-public partnership between the Government of Andalucía (Spain), the University of Granada and Merck Sharp and Dohme de España S.A.

GalChimia is a CRO that offers specialized services in Discovery, Process, and Analytical Chemistry for the pharma, biotech, and agrochemical industries. The passion for chemistry of GalChimia’s team has become a referent throughout the years, transforming the company into a European leader in Chemical Synthesis.

We not only make molecules, we foster innovation and provide a dynamic environment to continually push the boundaries of organic chemistry and help you succeed in your R&D projects.

Who we are :

Greenpharma is a CRO SME of 12 people, specialised in natural compound studies for cosmetic, food and pharmaceutical industries.
Built around an innovative technological platform, Greenpharma succeeded to gather expertise in wide and complementary fields such as chemoinformatic, pharmacognosy, medicinal & analytical chemistry, pilot scale extraction and formulation. This has led to a unique know-how in natural compound & extract selection, extract purification, metabolite measurement, homology modelling, virtual screening (e.g. Selnergy™), lead optimisation, ADMET prediction and database building. Greenpharma approach has led to several patents on bioactive (natural or synthetic) molecules and extracts.

What we do:

Greenpharma provides natural or synthetic compounds for high throughput screening. It utilises in silico tools to select the most relevant molecules (we have access to a database of 20 millions commercial compounds).

We provide the industries of pharmacy, cosmetics and agro-food with innovative bio-active molecules through R&D projects.
Our services include:

• Phytochemistry: development of methods for extraction, purification (until pilot scale) and characterisation of metabolites in complex matrices, activity-guided fractionations;

• Molecular modelling: ligand and structure-based virtual screening, QSAR, in silico activity identification (eg drug repositioning, identification of activities for natural compounds...) with our proprietary tool Selnergy;

• Knowledge management: database design and building.

• Medicinal chemistry: synthesis on demand, lead optimisation, natural compound mimics (eg. Pyrazolotriazine...), library design...

• Pilot extraction: development of pre-industrial method to produce cosmetic/food ingredients

• Formulation: development of formulation for cosmetic and dermocosmetic products