CONFORMA NV

Welcome to SIRIO Europe, member of the Sirio Pharma Group with more than 25 years of experience in development and contract manufacturing of nutraceutical and pharmaceutical private label products.

We are formulation experts. We support your business with innovative specialties that makes you stand out in the market.

GMP XRPD and SAXS Studies of Pharmaceuticals
DANNALAB is an independent contract research company that specializes in physico-chemical studies of pharmaceuticals, biopharmaceuticals and drug delivery systems. To date we have successfully completed more than 450 projects, with 60+ active pharmaceutical substances.

Our core expertise relates to X-Ray Powder Diffraction (XRPD or XRD) and Small Angle X-Ray Scattering (SAXS), combined with a range of complementary techniques.

At DANNALAB we use XRPD (XRD) to identify the polymorphic type and crystallinity of an active pharmaceutical ingredient (API) in its pure form, as well as in formulation or dosage forms. We support our customers during research, pre-formulation and formulation stages. XRPD methods for API characterisation are also applied during stability studies and used for quality control during batch release.

Small Angle X-Ray Scattering (SAXS) to Study Drug Delivery Vehicles and Biologics:
We use SAXS to study the structure of drug delivery systems - micelles, liposomes and nanoparticulates. We also use SAXS to study the higher-order structure of biologics, their aggregation pathways and their stability patterns. You can find more information on our drug delivery and biopharmaceuticals pages.

Pharmaceutical Patents
To ensure effective and safe intellectual property management, we offer a range of services related to pharmaceutical patents.

Good manufacturing Paractice (GMP) Quality System
Among our services we offer method development and validation. Our facility and procedures are compliant with the cGMP quality system. The methods we offer are developed according to USP <941>, Ph.Eur. <2.9.33> and ICH guidelines.

DEMO S.A. Pharmaceutical Industry is an industrial and commercial organization, active in the development, production and sales of pharmaceutical products.
The company’s manufacturing plant in Krioneri of Attica, is the largest in Southeastern Europe and one of the world’s largest, with state of the art facilities of 57,000 m2, including and a very hi- tech Quality Control Laboratory of 2,000+ m2.
DEMO S.A. is one of the major pharmaceutical manufacturers in Greece with a strong presence in the hospital market, ranking first among all the Greek pharmaceutical companies in terms of units sold. Our product portfolio includes injectable generic pharmaceutical formulations from several therapeutic categories: Injectable products of all forms such us Liquid injectables in glass ampoules, vials & bottles, sterile powders and freeze – dried formulations, Lyophilised products, Emulsions, Penems, Penicillins, Cephalosporins, Solutions & Suspensions for nebulization, medical devises and food supplements. It also performs an extensive R&D program for controlled release injectables.

DEMO S.A. has faithfully served its export orientation over the last years, with its sales network expanding to Europe, Asia, Africa,the Middle East, South America and Oceania. The company exports 84% of its annual production and is rapidly expanding its range of products to international markets.
Our company is a registered supplier of the United Nations, UNICEF, World Health Organization, MSF and the International Red Cross. With 2500+ approved products in 85 countries worldwide and 970 employees, DEMO aims to reliably meet the needs of the market in Greece and internationally. Our cutting edge production facilities allow us to offer our partners services such as:
• Worldwide distribution opportunities
• Out-licensing services
• Contract manufacturing operations.

Design Plus Health & Beauty is the UK specialist, one stop sachet manufacturer from development, testing, design, manufacture and fulfilment. We promote innovation from concept creation to delivery of market ready products. With all of our service centres under one roof we’re the perfect partner to help your health and beauty brands grow.

Established in 2000, Design Plus Health & Beauty has grown from a privately-owned company, to be part of DCC Health & Beauty Solutions - one of Europe’s leading outsourced service providers to the health and beauty sector.

Design Plus work with a range of clients including internationally recognised cosmetic brands to specialist medical suppliers, leading the way in full-service manufacture, formulation development and bespoke filling and packaging.

The company’s product and service range include;

• Conventional and shaped sachets filled with liquids, powders, wipes and capsules
• Bottle & tube filling
• Product formulation
• Private Label

Design Plus Health and Beauty bring together a purpose-built facility, years of expertise, state of the art technology and a network of industry specialists. We’re proud to have a dedicated team of 94 employees at our 34,000 sq. ft Morecambe site complete with account management, laboratory, quality control, finance, marketing, manufacturing, production and warehouse departments.

We’re an expert and personable team aligned in 4 common core values for what we do; partnership, integrity, excellence and safety.

Design Plus is part of Laleham Health & Beauty. A subsidiary of DCC Plc. We’re proud to be part of DCC plc; an ambitious and entrepreneurial FTSE 100 company. DCC plc employ approximately 11,500 people across four divisions and operate in 17 countries. To find out more visit www.dcc.ie.

Who are we?
Efarmes is a generic pharmaceutical company devoted to develop and manufacture generics for third parties all over the world. Efarmes Generics Company is part of Lacer Group. Our head offices, manufacturing site with EU cGMP’s and R&D area are in Barcelona.

What we do?
Efarmes Generics Company seeks partners that want to in-license and market the generics. Our partners are both multinational and local pharmaceutical companies on the five continents. Efarmes Generics Company offers tailored-made proposals such as full development and manufacturing of generic pharmaceutical products ready to be marketed by third parties under their own brand name, co-development of generic products, and contract manufacturing.

How we do it?
Efarmes Generics Company covers all levels from formulation to finished product delivery. Efarmes Generics Company currently supplies finished dosage forms to many key players all over the world. Our manufacturing site plant produced last year 24 M units (3.240 batches) with 99,9% Quality Control Conforming.

Our Business Proposal
Our main business model is the out license and supply of generic finished dosage forms. Our dossiers are in EU CTD format and ready to file. We have some MAs available in Europe.

Dossiers ready to file:
- Rasagiline (Parkinson’s diseases)
- Alprazolam (Anxiolytic)
- Deflazacort (Corticosteroid)
- Modafinil (Narcolepsy)
- Sildenafil (Erectil Dysfunction)
- Pioglitazone (Diabetes)
- Rivastigmine (Alzheimer diseases)

Dossiers under development:
- Olmersartan + Amlodipine + Hidroclorothiazide (Hypertension). Q2 2016 Bioequivalence studies on-going.
- Tapentadol, retard tabs, (Neurophatic Pain). Dossier will be available in 2018.

Products which are subject to patent are currently not offered or made available in countries where patents are in force. No orders or deliveries prior to the expiry date of valid patents are possible.

Please, contact us on generics@efarmes.es