Concert Pharmaceuticals, Inc.

Orphagen discovers and develops small molecules to drug targets that have significant unrealized potential in areas of high clinical need. We focus on the unexplored or “orphan” members of the nuclear receptor family. Nuclear receptors have been a rich source of successful drugs.

Orphagen has identified drug-like small molecules to several orphan nuclear receptors and has described efficacy in animal models of disease. An early success led to a partnership with Japan Tobacco (JT) Pharma to discover and develop oral drugs to treat psoriasis and other autoimmune diseases. This partnership was the first in the industry for the nuclear receptor ROR-gamma. JTE-451, a product of the JT Pharma partnership, entered Phase 2 trials this year (in 2019).

Orphagen has two major internal programs. One is to develop antagonists to the orphan nuclear receptor steroidogenic factor-1 (SF-1) for adrenocortical cancer (ACC) and other endocrine conditions. The second focuses on inflammatory disease. Orphagen also provides assay and screening services for the nuclear receptor family.

Health Decisions is a full-service CRO specializing in clinical studies of therapeutics for women’s health indications and studies of diagnostics for all therapeutic areas. Health Decisions has conducted more than 300 trials since its inception, including 140 trials in women-only indications. Our expertise enables us to address the challenges of developing women’s health products in areas including gynecology, contraception, sexual health, infertility, obstetrics, menopause and osteoporosis as well as other indications that affect women disproportionately such as autoimmune disorders. Health Decisions is headquartered in Durham, NC.

BioAgilytix is a leading global contract research organization focused on supporting pharmaceutical and biotech partners in all phases of drug development. With laboratory locations in North Carolina’s Research Triangle Park; Cambridge, Massachusetts; San Diego, California and Hamburg, Germany, BioAgilytix provides PK, immunogenicity, biomarkers, and cell-based assay services supporting the development and release testing of biologics across a number of industries and disease states.
BioAgilytix offers assay development, validation, and sample analysis under non-GLP, GLP, and GCP, as well as GMP quality control testing (i.e., product release testing, stability testing, etc.) BioAgilytix also offers diagnostic testing services at its CLIA-certified, CAP-accredited Boston laboratory.
BioAgilytix’s team of highly experienced scientific and QA professionals ensures high-quality science, data integrity and regulatory compliance through all phases of clinical development. BioAgilytix is a trusted partner to many top global pharmaceutical and biotech companies. For more information, visit www.bioagilytix.com.

Akston Biosciences Corporation leverages its novel fusion protein platform to develop and manufacture new classes of biologics, including vaccines, ultra-long-acting insulins, and autoimmune disease therapies. Founded by the team that developed the world’s first clinical glucose-responsive insulin at SmartCells, Inc., Akston’s COVID-19 vaccine candidate is in Phase II trials in the Netherlands. It has partnered with Dechra Pharmaceuticals PLC to commercialize once-a-week canine and feline insulin therapies. The company employs 35 people, has over 3,500 ft2 of research laboratory space and a 12,400 ft2 GMP clean room biologics manufacturing facility.

Athens Research and Technology Inc. located in Athens, GA USA is a Life Sciences Research Reagent Manufacturer providing the purest quality native human reagents for academic, institutional and commercial pharmaceutical uses. Our research reagents are actively being used by the research communities for the study of inflammation, autoimmune disease, cancer, coronary disease, Alzheimer’s disease and more.
We are expert in the purification of human proteins from plasma, erythrocytes, neutrophils, and other tissues. We are also accomplished in the purification of proteins from other species.

For the Diagnostic Manufacturer we provide protein components for diagnostic kits, screenings, and cell culture media. Please visit our website to see our entire selection of purified proteins, antibodies and custom purification services.

Our team of Project Leaders provide expert technical support for all products and services. We are ISO9001:2015 certified and welcome the opportunities for strategic sourcing vendor relationships.