CHEM-X-INFINITY

Who we are :

Greenpharma is a CRO SME of 12 people, specialised in natural compound studies for cosmetic, food and pharmaceutical industries.
Built around an innovative technological platform, Greenpharma succeeded to gather expertise in wide and complementary fields such as chemoinformatic, pharmacognosy, medicinal & analytical chemistry, pilot scale extraction and formulation. This has led to a unique know-how in natural compound & extract selection, extract purification, metabolite measurement, homology modelling, virtual screening (e.g. Selnergy™), lead optimisation, ADMET prediction and database building. Greenpharma approach has led to several patents on bioactive (natural or synthetic) molecules and extracts.

What we do:

Greenpharma provides natural or synthetic compounds for high throughput screening. It utilises in silico tools to select the most relevant molecules (we have access to a database of 20 millions commercial compounds).

We provide the industries of pharmacy, cosmetics and agro-food with innovative bio-active molecules through R&D projects.
Our services include:

• Phytochemistry: development of methods for extraction, purification (until pilot scale) and characterisation of metabolites in complex matrices, activity-guided fractionations;

• Molecular modelling: ligand and structure-based virtual screening, QSAR, in silico activity identification (eg drug repositioning, identification of activities for natural compounds...) with our proprietary tool Selnergy;

• Knowledge management: database design and building.

• Medicinal chemistry: synthesis on demand, lead optimisation, natural compound mimics (eg. Pyrazolotriazine...), library design...

• Pilot extraction: development of pre-industrial method to produce cosmetic/food ingredients

• Formulation: development of formulation for cosmetic and dermocosmetic products

Spectrum Info Ltd., a part of Life Chemicals Inc., is a contract research organization (ISO 9001:2015 certified).

Spectrum Info offers its expertise in custom synthesis and contract research, covering all aspects of lab-scale organic and medicinal chemistry. The services offered include:
• Multistep synthesis of complex organic molecules in mg to kg scale
• Synthesis of element-organic compounds (phosphorus-, fluorine-, sulfur-containing)
• Synthesis using organometallic reagents and transition-metal catalysed reactions
• Synthesis of reference compounds and small compound libraries
• Conformational restriction strategy
• Fluorine-containing 3D Molecular Toolkit
• Synthetic procedure development
• Process optimization and scale-up studies
• Collaborative or contract research projects to develop and synthesize new compounds for specific functions

Our products
• Functional polymethine dyes
o IR-absorbers
o NIR solvent soluble dyes
o Solvent soluble dyes
o Fluorescent dyes capable of covalent binding
o AgHal Sensitizers
o J-aggregated dyes
• Building blocks for molecular preorganization
• Combinatorial building blocks
• Fine chemicals

For any queries and orders, please contact us at spec-info@spec-info.com.

GEM FORLAB gives continuity to the experience of ABLE Biosciences as a global provider of scientific technology and services to the Life Science industry. It delivers solutions to companies of all size and shapes.
GEM FORLAB performs its activities by means of three technology areas:
Organic Chemistry
Mass Spectrometry & Proteomics
Cell and Molecular Biology & Immunoassay

ABLE Biosciences is the Test Facility GLP certified for small and large molecules quantitative analysis in biological matrices by means of Mass Spectrometry, Immunometric assays and qPCR and it is included in OsSC register of Private Laboratories qualified to perform analysis on samples derived from drug clinical trials (phase I-II-III) in compliance with GCP.

The Chemistry Unit provides all essential components for early drug discovery such as synthesis of chemical intermediates, process impurities, reference compounds, drug metabolites, and pro-drug; lead generation and optimization; bioconjugate chemistry; targeted molecules for MRI and others Molecular Imaging techniques.

UNDER CONSTRUCTION - ATG is a synthetic biology and biotech company. We combine proprietary analytical and synthetic bioinformatics tools and expertise with systems for the design, assembly and expression of multi-gene and multi-peptide constructs.
Products and services for drug discovery, industrial and medical biotechnology, molecular diagnostics, and bioengineering.
* Multi-gene recombineering and expression systems for E.coli, insect and mammalian cells (Toggle, MultiLabel)
* Tailor-made expression systems for other (micro)organisms based on a modular assembly strategy (Toggle)
* Proprietary multi-peptide library design tool + biosystems-based multi-peptide library construction and expression system (PepID) for rationally designed bio-peptide libraries. Assess, identify (map) and verify peptide epitopes, antibodies, or protein-protein-interactions in diagnostics and therapy.
* Gene intelligence solution EvoMAG for multi-parametric complex gene / (artificial) combinatorial gene cluster design as well as formal and operational optimization and moldeling of genes, genetic elements and expression cassettes for diverse target/production organisms (e.g. for functional enzyme optimization, metabolic engineering, signal pathway analysis, etc.)
* Gene synthesis of genes and gene clusters
* Plasmid production and purification
* State-of-the-art computational biology solutions / analysis for immunomics, metabolomics, gene expression analysis in your target organism of choice, etc.

Aurora Fine Chemicals is a privately held company that was founded in 1990. As a chemicals R&D supplier we offer chemicals for R&D, drug discovery service, compound libraries and custom synthesis. We have one of the largest collections of 18.1 mln. chemicals available in stock and our docking software delivers hits/leads of very high quality in short time.

Our staff consists of highly qualified individuals with Bsc, Msc and Ph.D. degrees in chemistry, as well as excellent laboratory technicians. In our Molecular Modeling Group are professionals specializing in computational drug design. They possess many years experience of working in the chemistry of heterocycles, carbohydrates, nucleosides and elemental organic compounds. Aurora has significant expertise in synthesis of all types R&D chemicals for drug discovery like small molecules, natural products and peptides. Parallel synthesis with well-designed, targeted and fragment-based libraries is the favored approach to lead optimization. Rational design is the strategy for projects driven by structural biology, such as enzyme inhibitors or protein interactions.

We own a large library of 18.1 million stocked compounds for R&D. Our substances are used in many research labs all over the world. We offer structures for biochemical and chemical research. Our products are applied in pharmaceutical development, diagnosis, and in chemical production.

Several laboratories for synthesis with modern equipment such as reactors, autoclaves, thermostats and hydrogenation equipment are available.

Intermediates and final products are analyzed by GC, HPLC, IR, NMR, MS, elemental analysis, atom-absorption analysis and crystallographical methods.

The main advantage of Aurora's own software is the quality of the underlying physical models. Aurora's software derives molecular properties from first principles based on direct models using advanced quantum mechanical analysis of molecular interactions and thermodynamics.