Cardiovascular Clinical Sciences

Kinexus Bioinformatics Corporation maps and monitors the molecular communications networks of living cells for biomedical research into the diagnosis, prognosis and treatment of human diseases. In particular, the company tracks enzymes called protein kinases that control other proteins by carrying out their phosphorylation at regulatory sites known as phosphosites. Phosphosites act as on/off switches for proteins. Their malfunction has been linked to more than 400 human diseases, including cancer, cardiovascular disease, diabetes and inflammation.

Currently, Kinexus measures the presence and activation states of over 650 different protein kinases and other regulatory proteins and many of their phosphosites in cell and tissue specimens through our integrated platform of cell culture, protein microarray, immunoblotting, mass spectrometry and immunohistochemistry services.

These innovative proprietary services utilize unique and stringent screening methods to facilitate the discovery and validation of biomarkers, drug targets and the rapid exclusion of inappropriate drug leads in the early stages of the drug discovery process. This is further augmented by a suite of open source, online bioinformatics services that are offered by Kinexus. Our bioinformatics studies are helping us to create new tools for biomedical research that include enzymes, antibodies and peptides.

For over 12 years, Kinexus has provided our unique services to over 1600 laboratories in 35 countries.

Amarex is a global, full-service Contract Research Organization (CRO), whose leadership team has significant expertise conducting biomedical research, and whose combined experience includes the design and conduct of several hundred clinical research projects in many therapeutic indications. Amarex provides comprehensive services in Project Management (Phase I-IV, BE/BA, PK/PD), Regulatory Affairs (FDA Applications and meetings, Applications to International Health Authorities, GxP Compliance Audits), Clinical Operations, Adaptive Study Designs, Statistical Analysis, Data Management, Medical Monitoring, Safety and Pharmacovigilance, and General Consulting. Amarex can take your product through the entire approval process, from creating the regulatory approval strategy, to conducting trials, to writing the marketing approval application. Join our growing list of clients with approved products. Amarex provides high quality and cost efficient services.

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Celerion, a leader in early clinical research, delivers Applied Translational Medicine. Celerion applies our expertise and experience to translating information gained in research discoveries, to knowledge of drug action and effect in humans to support early drug development decisions and the clinical pharmacology labeling of new medicines.

With over 40 years of experience and 600 global clinic beds (including 24 in-hospital), Celerion conducts and analyzes First-in-Human, clinical proof-of-concept, cardiovascular safety (TQT, robust QT), ADME and NDA-enabling clinical pharmacology studies. Celerion provides expertise on modeling and simulation, study design, medical writing (protocols and reports), clinical data sciences, biostatistics, and PK/PD analysis as well as small and large molecule bioanalytical assays through clinical drug development. Regulatory, drug development and program management complement Celerion’s service offerings.

Our operations are strategically located in:
Lincoln, Nebraska (Corporate Headquarters)
Philadelphia, Pennsylvania
Phoenix, Arizona
Belfast, Northern Ireland,UK
Zurich, Switzerland
Richmond, Virginia
Montreal, Quebec, Canada

For more information, visit: www.celerion.com

As the drug development business of Laboratory Corporation of America Holdings (Labcorp) and the world’s most comprehensive drug development #CRO service company, we have helped pharmaceutical and biotech companies develop 100% of the top 50 prescription drugs in the marketplace today.

Because of our broad experience and specialized expertise, we’re in a unique position to supply insights that go above and beyond testing. Together with our clients, we create solutions that transform potential into reality.

Founded in 1989 by the University of Colorado, CPC has two divisions. CPC Clinical Research is an academically led, non-profit, clinical research organization offering Phase 1 - 4 clinical research leadership and management services to sponsors around the world. CPC Clinical Research specializes in innovative research including a proprietary program, the Endpoint Quality Intervention Program (EQuIP), that helps reduce variability in the collection of endpoint data, allowing more definitive answers to the study objectives.

CPC Community Health creates innovative and educational programs to implement established cardiovascular prevention national guidelines and best evidence in Colorado communities resulting in improved cardiovascular health.

CPC is affiliated with the University Of Colorado School Of Medicine, Denver Health and the National Jewish Health. CPC is also the clinical trials arm of the University of Colorado Charles C Gates Center for Regenerative Medicine & Stem Cell Biology whose goal is to understand the biology of stem cells in order to develop new therapies for debilitating diseases such as heart diseases and vascular diseases.

CPC CLINICAL RESEARCH MISSION

To unite academic leadership with operational expertise to optimize the quality of clinical research and improve health.

CPC COMMUNITY HEALTH MISSION

Our mission is to improve the health of all Coloradans by creating innovative community health programs that deliver evidence-based interventions.

Visit us at www.cpcmed.org and www.communityhealth.org