BioBlocks, Inc.

Founded in 2000, CanAm Bioresearch is located in Winnipeg, Canada. CanAm Bioresearch is an established pharmaceutical contract research organization focused on pre-clinical drug discovery.

CanAm Advantages:

• Integrated CRO with flexible access to chemistry, biology and analytical
• Company leadership has experience discovering NCEs now on the market
• Highly competent and experienced research team - proven ability to deliver clinical candidates
• Outstanding skills to tackle difficult chemistry and solve complex problems through an integrated multi-disciplinary approach
• Customer focused: we operate as your own research team on your terms
• Central time zone convenient for all of North America and Europe

CanAm's clientele includes startup, small and large pharmaceutical companies, and academic institutions. Research contracts can range from simple chemical synthesis or single compound testing in our ADME and biological assays, to FTE-based full scale integrated discovery projects. We are experienced in protecting client confidentiality and intellectual property.

Medicinal Chemistry and Custom Chemical Synthesis Solutions
• Chemical synthesis of analogs
• Chemical libraries based on our collections of capping groups
• Rapid delivery, typically weekly
• Experience in hit to lead generation and optimization
• Difficult chemistry welcome!

Analytical Chemistry Solutions

• Pharmacokinetics experiments
• Tissue distribution
• Metabolite identification
• Stability studies
• Determination of chemical purity
• Solubility studies

Biological Solutions
Assays include:
• Biochemical
• Electrophysiological
• Metabolic stability
• Cellular penetration

FTE contracts:
• Very competitive rates compared to US and Western Europe
• Project leadership and medicinal chemistry guidance available

Fee for service contracts:

• Custom synthesis of any organic molecule
• Up to 1 kg scale synthesis

Drug Discovery Alliances is a provider of chemistry and formulation services bringing together scientific expertise and support during all stages of the R&D continuum for emerging biotechs, existing multinationals and the United States government. We provide a global service where our partners – located in N. America, China, Japan, Czech Republic, England, Germany and Italy – cover four key services:

Consulting
• CMC Project Management
• GMP Auditing
• Licensing
• Sourcing & Procurement

Drug Discovery
• Medicinal Chemistry

R&D/Pre-Clinical
• Analytical Method Development
• Catalysis Screening
• Crystallization
• Metabolites, Impurities ID & Synthesis
• Process Research
• Reference Standards
• Solid Form Capabilities

Manufacturing (Phase I-III)
• Advanced Intermediate Manufacturing
• API & Commercial Manufacturing
• cGMP Manufacturing
• Final Drug Product Manufacturing
• Formulation Development
• Quality and Regulatory Support
• Raw Material Manufacturing

Chemistry Technology Platforms
Aseptic Fill & Finish
• Chlorination
• Chromatography
• Cryogenic
• Distillation
• Fermentation
• Heck Reactions
• HPAPI / High Potency
• High Pressure
• High Temperature
• High Throughput / High Resolution X-ray Diffraction
• Hydrogenation
• Lyophilization
• Nitration
• Pastillation
• Phosgenation
• Polymorph Screening
• Powder Filling
• X-ray Crystallography

Project Examples
• 4 year program for development of Regulatory Starting Material supporting NDA filing for a neurology product
• Urgent API consulting for Clinical Phase III with supplier change and identified savings of $10M
• CMC project consulting on pre-IND candidates ($760M) for a CNS product licensed by Astellas
• Generic new formulation consulting supporting Clinical Phase III for 505(b)(2) for hypertension product
• Commercial API manufacture for ophthalmology product sourcing key suppliers leading to successful FDA approval
• Phase III API for antibody conjugate for oncology identifying key supplier

Shamrock Structures offers protein crystallography, medicinal chemistry and cell biology research services to enable clients to reduce the time from protein target to lead compound generation.

Shamrock Structures is a drug discovery research services company founded in 2003 to provide pharmaceutical researchers with access to unrivaled technologies and expertise for three dimensional protein structure determinations. Possessing structural information empowers researchers to conduct structure-based drug discovery.

Through our staff and our network of partners, we provide services including:

-Protein purification
-Protein crystallization
-Synchrotron X-ray data collection
-Structure determination and refinement
-Medicinal chemistry
-Cell biology

We are advantageously located a mile from the U.S. Department of Energy’s Argonne National Laboratory with whom we have an agreement to efficiently access the Advanced Photon Source (APS). The APS technology is the premiere 3rd generation X-ray synchrotron light source in North America facilitating fast and efficient protein structure determination.

Shamrock Structures is Accelerating Structure-Based Drug Discovery!




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Structure based Design, Inc (SBD) provides gene-to-lead integrated drug discovery services and engages in novel drug discovery partnerships. We specialize in protein production, protein structure determination, assay development, structure-based drug design (SBDD), and fragment-based drug design (FBDD) to support lead discovery and optimization. We have worked on over 80 different drug discovery projects and solved hundreds of co-crystal structures for our clients and for internal projects since our inception in 2007. We are conveniently located in San Diego and provided unparalleled scientific support. We have accelerated first-in-class drug discovery efforts using structure-based design approaches, shaving years and millions of dollars off compound development. Drug discovery programs supported by our work have resulted in more than ten clinical stage compounds for our clients.
Service Package
SBD’s services are milestone based & customer driven. We have flexible service packages that we adapt to meet your research goals. All of our packages include bi-weekly progress updates:

Service package I: Crystals & Structures
Crystallize target protein provided by client
Determine apo-crystal and co-crystal structure
Structure analysis, deliver results
Service package II: Protein & Co-crystal Structures
Design construct, express, purify, and crystallize target.
Determine co-crystal structures with one to ten ligands
Analyze structures and present results
Service package III: High-Throughput Crystal Structures
Construct design, large scale protein purification at SBD
High throughput co-crystallization.
Determine 20-30 co-crystal structures to fully support a client’s drug discovery process.
Service Package IV: Early Lead Development Partnership
Construct design, large scale protein purification
High throughput co-crystallization
Determine co-crystal structures to fully support medicinal chemistry and compound optimization.
Activity assays, cell-based assays, binding affini

SynChem, Inc., founded in 1997 and headquartered in Elk Grove Village (a suburb of Chicago), Illinois, is a chemistry-based contract research organization specializing in organic synthesis, process development and medicinal chemistry. Since its inception, SynChem has completed more than 4,500 projects for wide range of customers, including multi-national pharmaceutical companies, biotech companies, drug discovery companies, chemical and agrochemical companies, generated more than 15 scientific publications, obtained 4 US Patents. Three projects initiated at SynChem reached marketplace by the continued efforts of the customers.