APExBIO Technology LLC

Founded in 2004, Pharmaron is a cutting-edge, fully integrated pharmaceutical R&D service platform supporting the life science industry. The company has invested in its people and facilities and established its comprehensive service offerings throughout the pharmaceutical R&D lifecycle. With operations in China, the US and the UK staffed by more than 11,000 employees, Pharmaron has an excellent track record in delivering end-to-end R&D solutions to its partners globally and enabling them to accelerate their novel drug discovery and development process.

Pharmaron is a contract research organization (CRO).

Services:
* Synthetic, medicinal and analytical chemistry services
* Biology services
* DMPK services
* Pharmacology services
* Drug safety assessment services
* Radiochemistry and isotopically labelled metabolism services
* Chemical & pharmaceutical development services
* Clinical development services

www.pharmaron.com

CRO - Contract Research Organization
Library Synthesis
CADD
Bioorganic Chemistry
Discovery Process Chemistry
Radiolabelled Chemical Synthesis
ChemInformatics
in vitro Biology
in vitro Screening
Structural Biology
in vivo Pharmacology
Animal Disease Models
ex vivo Pharmacology
Biomarkers
in vitro ADME
in vivo PK
PKPD
QA
Regulatory Affairs
Discovery Biologics
Process Chemistry
API Manufacturing
Material Science
Formulation Development
Drug Product Manufacturing
Toxicology
Safety Pharmacology
Genetic Toxicology
DART
Pathology
Immunotoxicity
Bioanalytical
14C / Carbon-14 Radiosynthesis
3H / Tritium Radiosynthesis
QWBA
mARG
Clinical AME
Mass Balance
Metabolite Profiling
Microdosing Phase 0
Absolute Bioavailability
DDI
First-in-Human (FIH)
Thorough QT(TQT)
Ethnobridging

Confluence Discovery Technologies, a development service company, can help in many phases of the discovery process based on its extensive experience in drug discovery and clinical development. Our proven experience with the discovery and development process coupled with the high-tech approach used by our experts makes Confluence Discovery Technologies your affordable on-shore contract research firm. Our highly trained scientists operate a state-of-the-art laboratory to support Cell and Molecular Biology, Biochemistry / Enzymology, Biomarker Development & Testing, Immunology, In Vivo Efficacy Models, Medicinal, Computational, and Bioanalytical Chemistry, and Project Management in order to make your project a success.

Productivity is a function of experience, expertise and equipment. Confluence Discovery Technologies provides the flexibility and resources necessary to maximize your research initiatives.



• Providing services spanning from one time consultation through independently driving a drug discovery program



• Complete medicinal chemistry design/synthesis, biochemical testing, cell biology testing

• Biomarker assay development

• Project leadership

• Effective decision making

• Innovative, focused and milestone-driven projects



Industry Leading Strength in Mechanistic Enzymology

• Lead series prioritization

• Inhibitor mechanism characterization

• Real vs artifact determination



Skilled Assay Development, Validation and Execution

• Multiple formats, readouts, validation, comparisons

• Data reduction experts

• HTS format experience

EpigenDx was incorporated in 2006 as a genomic and epigenomic research company specializing in disease biomarker discovery, validation and molecular diagnosis, with an unmatched expertise in the field of DNA methylation analysis.

EpigenDx provides superior products and laboratory services for scientific researchers from academic, government and industrial communities from all over the world. Our commitment to quality reflects our desire and dedication to provide the best products and services to our customers. EpigenDx has extensive knowledge and expertise in Pyrosequencing, bisulfite sequencing, and various epigenomic research analysis techniques and methods stemming from our years of experience in the industry.

EpigenDx Lab Services include:
DNA Methylation
- Bisulfite Pyrosequencing: determine loci specific methylation and global methylation levels individual CpGs sites
- Targeted MethylSeq: determine methylation levels in multiple targeted regions at base pair resolution
Expression Analysis
- Gene and miRNA profiling using Affymetrix Gene Chip arrays
Mutation & SNP Analysis
- Quantative mutation analysis using Pyrosequencing for minor allele detection, allele specific expression
- 1.8 million SNPs and copy number changes using Affymetrix 6.0 Array

EpigenDx products include:
DNA Methylation Controls: low and high methylated genomic DNA for studying human, mouse, rat genes
Validated loci specific DNA methylation assays for multiple platforms including bisulfite sequencing, bisulfite Pyrosequencing, and realtime based PCR analysis. All assays are validated for PCR bias or preferential amplification.
Methylation Panels including Stem Cell Panel, Cancer Panel, Immunology Panel, and CNS Panel. They are designed for bisulfite sequencing analysis using either Pyrosequencing or NGS platforms.

Invivotek LLC, a member of Genesis Biotechnology Group® (GBG) is a global pre-clinical contract research organization (CRO) specializing in small animal studies for drug discovery and early optimization. Invivotek's facility was opened in 2012 and our first commercial project launched in 2013.

Invivotek offers both custom and standard pre-clinical services for drug discovery and development programs for our clients. Invivotek’s portfolio includes animal models and bioassays designed to support in vivo testing of compounds related to Immunology and Inflammation, Oncology, Metabolic, and Cardiovascular diseases. Invivotek’s in vivo testing capabilities are supported by biochemical and molecular biology techniques as well as functional assays with primary cell cultures established from various mouse tissues under disease model and normal conditions. These assays provide tools to study the mechanism of action of various test therapeutics or potential target genes and to explore drug efficacy biomarkers. The collective experience across multiple therapeutic areas in conjunction with the business and project management skills of the team working in a state-of-the-art animal facility, position Invivotek as a leading provider of preclinical in vivo services.

Marin Biologic blends the fields of cell biology, immunology, molecular biology and biochemistry to tackle complex projects in an innovative and timely manner. We simultaneously utilize our in-depth scientific expertise to collectively approach projects to complement our client’s approach and meet the client’s needs.

Marin Biologic is a woman PhD owned and managed Contract Research Laboratory which specializes in the research, pre-clinical and clinical development and validation of cell based assays and immunoassays for biotech and pharmaceutical companies in Phase I/II or Phase III stages. Our unique approach to collaboration encourages scientists to talk to scientists to create better science.

We are compliant with U.S. FDA cGMP/GLP standards as well as ICH for all levels of clinical development. We employ these standards that are phase appropriate for your clinical development or research.

CEO and President Tania Weiss PhD founded Marin Biologic Laboratories in 1995 to be able to apply her enthusiasm for good scientific process to a broad array of client projects. As a result, the client list as well as the project list is very diverse over the history of the Company. Marin Biologic seeks out and attracts interesting and different scientific opportunities, which puts them at the forefront of scientific development.

Our Lab is located in Novato, California, halfway between San Francisco and the Napa and Sonoma Valleys.

Peter Ralph. PhD, VP Science, peter@marinbio.com
Tania Weiss, PhD, CEO, tania@marinbio.com

415 883-8000
Visit: www.marinbio.com to connect with us, or ask us a question.