Apex Molecular Ltd

UNDER CONSTRUCTION - ATG is a synthetic biology and biotech company. We combine proprietary analytical and synthetic bioinformatics tools and expertise with systems for the design, assembly and expression of multi-gene and multi-peptide constructs.
Products and services for drug discovery, industrial and medical biotechnology, molecular diagnostics, and bioengineering.
* Multi-gene recombineering and expression systems for E.coli, insect and mammalian cells (Toggle, MultiLabel)
* Tailor-made expression systems for other (micro)organisms based on a modular assembly strategy (Toggle)
* Proprietary multi-peptide library design tool + biosystems-based multi-peptide library construction and expression system (PepID) for rationally designed bio-peptide libraries. Assess, identify (map) and verify peptide epitopes, antibodies, or protein-protein-interactions in diagnostics and therapy.
* Gene intelligence solution EvoMAG for multi-parametric complex gene / (artificial) combinatorial gene cluster design as well as formal and operational optimization and moldeling of genes, genetic elements and expression cassettes for diverse target/production organisms (e.g. for functional enzyme optimization, metabolic engineering, signal pathway analysis, etc.)
* Gene synthesis of genes and gene clusters
* Plasmid production and purification
* State-of-the-art computational biology solutions / analysis for immunomics, metabolomics, gene expression analysis in your target organism of choice, etc.

Confluence Discovery Technologies, a development service company, can help in many phases of the discovery process based on its extensive experience in drug discovery and clinical development. Our proven experience with the discovery and development process coupled with the high-tech approach used by our experts makes Confluence Discovery Technologies your affordable on-shore contract research firm. Our highly trained scientists operate a state-of-the-art laboratory to support Cell and Molecular Biology, Biochemistry / Enzymology, Biomarker Development & Testing, Immunology, In Vivo Efficacy Models, Medicinal, Computational, and Bioanalytical Chemistry, and Project Management in order to make your project a success.

Productivity is a function of experience, expertise and equipment. Confluence Discovery Technologies provides the flexibility and resources necessary to maximize your research initiatives.



• Providing services spanning from one time consultation through independently driving a drug discovery program



• Complete medicinal chemistry design/synthesis, biochemical testing, cell biology testing

• Biomarker assay development

• Project leadership

• Effective decision making

• Innovative, focused and milestone-driven projects



Industry Leading Strength in Mechanistic Enzymology

• Lead series prioritization

• Inhibitor mechanism characterization

• Real vs artifact determination



Skilled Assay Development, Validation and Execution

• Multiple formats, readouts, validation, comparisons

• Data reduction experts

• HTS format experience

Drug Discovery Alliances is a provider of chemistry and formulation services bringing together scientific expertise and support during all stages of the R&D continuum for emerging biotechs, existing multinationals and the United States government. We provide a global service where our partners – located in N. America, China, Japan, Czech Republic, England, Germany and Italy – cover four key services:

Consulting
• CMC Project Management
• GMP Auditing
• Licensing
• Sourcing & Procurement

Drug Discovery
• Medicinal Chemistry

R&D/Pre-Clinical
• Analytical Method Development
• Catalysis Screening
• Crystallization
• Metabolites, Impurities ID & Synthesis
• Process Research
• Reference Standards
• Solid Form Capabilities

Manufacturing (Phase I-III)
• Advanced Intermediate Manufacturing
• API & Commercial Manufacturing
• cGMP Manufacturing
• Final Drug Product Manufacturing
• Formulation Development
• Quality and Regulatory Support
• Raw Material Manufacturing

Chemistry Technology Platforms
Aseptic Fill & Finish
• Chlorination
• Chromatography
• Cryogenic
• Distillation
• Fermentation
• Heck Reactions
• HPAPI / High Potency
• High Pressure
• High Temperature
• High Throughput / High Resolution X-ray Diffraction
• Hydrogenation
• Lyophilization
• Nitration
• Pastillation
• Phosgenation
• Polymorph Screening
• Powder Filling
• X-ray Crystallography

Project Examples
• 4 year program for development of Regulatory Starting Material supporting NDA filing for a neurology product
• Urgent API consulting for Clinical Phase III with supplier change and identified savings of $10M
• CMC project consulting on pre-IND candidates ($760M) for a CNS product licensed by Astellas
• Generic new formulation consulting supporting Clinical Phase III for 505(b)(2) for hypertension product
• Commercial API manufacture for ophthalmology product sourcing key suppliers leading to successful FDA approval
• Phase III API for antibody conjugate for oncology identifying key supplier

Advanced Molecular Technologies Pty Ltd (AMT) is a contract research organisation (CRO) established in 2005, specialising in medicinal chemistry and custom organic synthesis. The provided services involve the synthesis of target molecules, the manufacturing (larger-scale) of chemical materials, analytical chemistry, chemical method development and optimisation, drug discovery and synthetic organic research.

AMT is also a manufacturer and supplier of chemicals in Victoria, Australia, distributing specialty products to partners, institutions and companies worldwide.

AMT has extensive experience in organoboron, organosilicon, PEG-linkers and fluorophore technology, with many of these discrete molecules available for purchase on their website. More recently, AMT is spinning-out its own initiatives through novel technology developed within the pharmaceutical and veterinary industries.

Equipped with a 400 MHz NMR machine, HPLC, GC, FT-IR and several other analytical pieces of equipment, AMT also readily provides analytical services to the chemical industry.

American Custom Chemicals Corporation (ACC Corporation) is a life sciences solutions provider to the biotech, pharma & chemicals industries.
• Custom Synthesis (lab scale to kilo scale) with 6-8 step synthesis for about $6000-$8000/100mg & $8000-$10,000/gm. Each custom synthesis comes with a COA, MSDS, HNMR, HPLC, MS, LC, MS, (CNMR & IR provided on request).
• Largest Active Pharmaceutical Intermediates library with around 4000 products
• Reference Standards for Kinases, GPCRs, Ion channels, Anti-HIV & Anti-HCV
• Over 6000 Medicinal Chemistry cores with 2-3 points of funtionalization.
• A catalog of over 100,000 products available for immediate sale via our website or through custom synthesis. All products come with appropriate documentation.
• Biologicals custom synthesis with focus on fermentation, peptides, proteins & antibodies.
• FTE for all your research needs with complete project management & weekly status reports on the experiments including spectra.