Acme Bioscience, Inc.

American Custom Chemicals Corporation (ACC Corporation) is a life sciences solutions provider to the biotech, pharma & chemicals industries.
• Custom Synthesis (lab scale to kilo scale) with 6-8 step synthesis for about $6000-$8000/100mg & $8000-$10,000/gm. Each custom synthesis comes with a COA, MSDS, HNMR, HPLC, MS, LC, MS, (CNMR & IR provided on request).
• Largest Active Pharmaceutical Intermediates library with around 4000 products
• Reference Standards for Kinases, GPCRs, Ion channels, Anti-HIV & Anti-HCV
• Over 6000 Medicinal Chemistry cores with 2-3 points of funtionalization.
• A catalog of over 100,000 products available for immediate sale via our website or through custom synthesis. All products come with appropriate documentation.
• Biologicals custom synthesis with focus on fermentation, peptides, proteins & antibodies.
• FTE for all your research needs with complete project management & weekly status reports on the experiments including spectra.

PREMIUM PHARMACEUTICAL INGREDIENTS - MANUFACTURED EXCLUSIVELY IN THE USA
BioSpectra is a US Based manufacturer of GMP, pharmaceutical grade ingredients, including Actives, Excipients, GMP Process Chemicals & Bulk GMP Buffers and Solutions. Our focus is small molecule synthesis and true, phase change multi-step purification for both traditional and bio-pharmaceutical applications. Our services include Contract GMP product development coupled with ongoing commercial manufacturing and regulatory support up to and including DMF submissions. All of our manufacturing processes are fully validated. Our US-GMP regulatory package complies with IPEC & ICHQ7 guidelines. Our onsite analytical testing capabilities include multi-compendial and custom specifications with full traceability and transparency of all raw materials and sources.

Our commitment is to quality, compliance and true, US-GMP manufacturing, testing and regulatory support is unparalleled. We own and operate out of 175,000 square feet of FDA registered & inspected GMP manufacturing space, under the most rigorous quality system while holding to the most stringent regulatory demands. Our goal is to be a valued partner in the secure supply chain and the solution to any key ingredient issue our customers may have.

GMP Product Categories:
• Bulk, GMP Biological Buffers
• Active & functional Excipients
• GMP Process Chemicals and Bulk GMP Solution Solutions

Custom GMP Services Include:
• Purification of Key Ingredients
• Full GMP Product Development
• Small Molecule Custom Synthesis
• API Development & Manufacturing
• Custom GMP Compounded Solvents & Solutions

Comprehensive Quality and Regulatory Program
• FDA Registered and Inspected
• Document Support - DMF Submissions
• Global GMP Requirements – US, IPEC, ICH Q7

Drug Discovery Alliances is a provider of chemistry and formulation services bringing together scientific expertise and support during all stages of the R&D continuum for emerging biotechs, existing multinationals and the United States government. We provide a global service where our partners – located in N. America, China, Japan, Czech Republic, England, Germany and Italy – cover four key services:

Consulting
• CMC Project Management
• GMP Auditing
• Licensing
• Sourcing & Procurement

Drug Discovery
• Medicinal Chemistry

R&D/Pre-Clinical
• Analytical Method Development
• Catalysis Screening
• Crystallization
• Metabolites, Impurities ID & Synthesis
• Process Research
• Reference Standards
• Solid Form Capabilities

Manufacturing (Phase I-III)
• Advanced Intermediate Manufacturing
• API & Commercial Manufacturing
• cGMP Manufacturing
• Final Drug Product Manufacturing
• Formulation Development
• Quality and Regulatory Support
• Raw Material Manufacturing

Chemistry Technology Platforms
Aseptic Fill & Finish
• Chlorination
• Chromatography
• Cryogenic
• Distillation
• Fermentation
• Heck Reactions
• HPAPI / High Potency
• High Pressure
• High Temperature
• High Throughput / High Resolution X-ray Diffraction
• Hydrogenation
• Lyophilization
• Nitration
• Pastillation
• Phosgenation
• Polymorph Screening
• Powder Filling
• X-ray Crystallography

Project Examples
• 4 year program for development of Regulatory Starting Material supporting NDA filing for a neurology product
• Urgent API consulting for Clinical Phase III with supplier change and identified savings of $10M
• CMC project consulting on pre-IND candidates ($760M) for a CNS product licensed by Astellas
• Generic new formulation consulting supporting Clinical Phase III for 505(b)(2) for hypertension product
• Commercial API manufacture for ophthalmology product sourcing key suppliers leading to successful FDA approval
• Phase III API for antibody conjugate for oncology identifying key supplier

Orochem is globally recognized as an organization that conceives, develops, and installs some of the most technologically viable solutions for “highest purities” for industrial or “metric ton” scale purification for API’s, nutritional supplements, fatty acids, and specialty sugars. Orochem provides Simulated Moving Bed (SMB) Chromatography technology for the laboratory scale, pilot scale and large-scale purification of commercially viable molecules for its customers around the world. Orochem’s products and services for Simulated Moving Bed Chromatography include Synthesis and manufacture of stationary phases “tailored for specific separations”, a uniquely engineered SMB system and the installation and commissioning of the SMB systems at customer sites with well-trained Orochem technical service engineers.
Orochem owns several manufacturing facilities around the world. The Lombard, Illinois, USA, facility has about 22,000 sqft, and the Naperville, Illinois, USA site has about 84,000 square feet of manufacturing area where most of the Membrane Filter Plates, Silica manufacturing, Silica bonding, Solid Phase Extraction products and HPLC Columns are manufactured. Orochem India, Mumbai has 20,000 square feet facility and manufactures Sample prep products for the Discovery & Clinical Research organizations in Asia. Simulated Moving Bed chromatography systems are designed, built and assembled completely at our US locations in Lombard and Naperville in Illinois.

Richman Chemical is a custom synthesis, chemical manufacturing, and raw materials sourcing provider to the life science and chemical industries.

Founded in 1988 by Edward Richman, Ph.D., Richman Chemical specializes in custom and contract manufacturing projects and the sourcing of hard-to-find chemicals. Richman Chemical uses its unique business model to help companies optimize production and improve process efficiency. Richman Chemical's main strength is in its ability to provide early-stage and established life science companies with flexible and cost effective solutions.

With nearly three decades of industry experience, Richman Chemical has earned a reputation as being an excellent partner and valuable resource for pharmaceutical, medical device, biotechnology, nanotechnology, venture capital, start-up, and specialty chemical companies.

We invite you to visit our website at www.richmanchemical.com.

To make a custom synthesis inquiry, click www.richmanchemical.com/custom-services-inquiry-form. To make an inquiry regarding specific products, click www.richmanchemical.com/raw-material-sourcing-inquiry.

Any interested parties wanting further information are welcome to contact our Executive Vice President, Christopher Kulp, via telephone at 215.628.2946 Ext.13 or via email at clk@RichmanChemical.com.